Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis.

Cancer research - 1 Jan 2012

Jarrett Stuart G, Novak Marian, Dabernat Sandrine, Daniel Jean-Yves, Mellon Isabel, Zhang Qingbei, Harris Nathan, Ciesielski Michael J, Fenstermaker Robert A, Kovacic Diane, Slominski Andrzej, Kaetzel David M

Abstract excerpt

Reduced expression of the metastasis suppressor NM23-H1 is associated with aggressive forms of multiple cancers. Here, we establish that NM23-H1 (termed H1 isoform in human, M1 in mouse) and two of its attendant enzymatic activities, the 3'-5' exonuclease and nucleoside diphosphate kinase, are novel participants in the cellular response to UV radiation (UVR)-induced DNA damage. NM23-H1 deficiency compromised the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxanthine Phosphoribosyltransferase

Share to Melanoma, Experimental

Share to Mice, Inbred C57BL

Share to Neoplasms, Radiation-Induced

Share to NM23 Nucleoside Diphosphate Kinases

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 22080566
DOI: 10.1158/0008-5472.CAN-11-1795
PMCID: PMC3251703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis.PMID 22080566Read ↗

NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma.Semantic proximity Read ↗

Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression.Semantic proximity Read ↗

Potential contributions of antimutator activity to the metastasis suppressor function of NM23-H1.Semantic proximity Read ↗

Multiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load.Semantic proximity Read ↗

The metastasis suppressor NM23-H1 possesses 3'-5' exonuclease activity.Semantic proximity Read ↗

DNA repair pathways and human metastatic malignant melanoma.Semantic proximity Read ↗

Ultraviolet radiation modulates DNA methylation in melanocytesSemantic proximity Read ↗

UVB mutagenesis differs in <i>NRAS</i> - and <i>BRAF</i> -mutant mouse models of melanomaSemantic proximity Read ↗

UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma.Semantic proximity Read ↗

Genome-wide maps of UVA and UVB mutagenesis in yeast reveal distinct causative lesions and mutational strand asymmetries.Semantic proximity Read ↗

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.Semantic proximity Read ↗

The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to MetastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.