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Article

UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma.

Life science alliance - 1 Sept 2021

Bowman Robert L, Hennessey Rebecca C, Weiss Tirzah J, Tallman David A, Crawford Emma R, Murphy Brandon M, Webb Amy, Zhang Souhui, La Perle Krista Md, Burd Craig J, Levine Ross L, Shain A Hunter, Burd Christin E

Abstract excerpt

BRAF-mutant melanomas are more likely than NRAS-mutant melanomas to arise in anatomical locations protected from chronic sun damage. We hypothesized that this discrepancy in tumor location is a consequence of the differential sensitivity of BRAF and NRAS-mutant melanocytes to ultraviolet light (UV)-mediated carcinogenesis. We tested this hypothesis by comparing the mutagenic consequences of a single neonatal,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34210801
DOI: 10.26508/lsa.202101135
PMCID: PMC8321651

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