The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.

doi:10.1111/pcmr.12735

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Article

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.

Pigment cell & melanoma research - 1 Mar 2019

Webster Joshua D, Pham Trang H, Wu Xiumin, Hughes Nicolas W, Li Zhongwu, Totpal Klara, Lee Ho-June, Calses Philamer C, Chaurushiya Mira S, Stawiski Eric W, Modrusan Zora, Chang Matthew T, Tran Christopher, Lee Wyne P, Chalasani Sreedevi, Hung Jeffrey, Sharma Neeraj, Chan Sara, Hotzel Kathy, Talevich Eric, Shain Alan, Xu Mengshu, Lill Jennie, Dixit Vishva M, Bastian Boris C, Dey Anwesha

Abstract excerpt

The deubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with a high risk of mesothelioma and melanocytic tumors. Here, we show that Bap1 deletion in melanocytes cooperates with the constitutively active, oncogenic form of BRAF (BRAFV600E ) and UV to cause melanoma in mice, albeit at very low frequency. In addition, Bap1-null melanoma cells derived from mouse tumors are more aggressive and...

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Identifiers

PMID: 30156010
DOI: 10.1111/pcmr.12735

Genes

BAP1
BRAF

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