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Article

The metastasis suppressor NM23-H1 possesses 3'-5' exonuclease activity.

The Journal of biological chemistry - 23 Apr 2004

Ma Deqin, McCorkle Joseph R, Kaetzel David M

Abstract excerpt

NM23-H1 belongs to a family of eight gene products in humans that have been implicated in cellular differentiation and development, as well as oncogenesis and tumor metastasis. We have defined NM23-H1 biochemically as a 3'-5' exonuclease by virtue of its ability in stoichiometric amounts to excise single nucleotides in a stepwise manner from the 3' terminus of DNA. The activity is dependent upon the presence of...

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Identifiers

PMID: 14960567
DOI: 10.1074/jbc.M400185200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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