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The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis

1 Jan 2020

Abstract excerpt

Metastasis suppressor genes (MSGs) inhibit different biological processes during metastatic progression without globally influencing development of the primary tumor. The first MSG, NM23 (non-metastatic clone 23, isoform H1) or now called NME1 (stands for non-metastatic) was identified some decades ago. Since then, ten human NM23 paralogs forming two groups have been discovered. Group I NM23 genes encode enzymes...

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PMID: 31993913
DOI: 10.1007/s12253-020-00797-0

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