Article
DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications.
Blood - 12 Jan 2012
Hou Hsin-An, Kuo Yuan-Yeh, Liu Chieh-Yu, Chou Wen-Chien, Lee Ming Cheng, Chen Chien-Yuan, Lin Liang-In, Tseng Mei-Hsuan, Huang Chi-Fei, Chiang Ying-Chieh, Lee Fen-Yu, Liu Ming-Chih, Liu Chia-Wen, Tang Jih-Luh, Yao Ming, Huang Shang-Yi, Ko Bor-Sheng, Hsu Szu-Chun, Wu Shang-Ju, Tsay Woei, Chen Yao-Chang, Tien Hwei-Fang
Abstract excerpt
DNMT3A mutations are associated with poor prognosis in acute myeloid leukemia (AML), but the stability of this mutation during the clinical course remains unclear. In the present study of 500 patients with de novo AML, DNMT3A mutations were identified in 14% of total patients and in 22.9% of AML patients with normal karyotype. DNMT3A mutations were positively associated with older age, higher WBC and platelet...
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