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Article

Biologico-clinical significance of DNMT3A variants expression in acute myeloid leukemia.

Biochemical and biophysical research communications - 9 Dec 2017

Lin Na, Fu Wei, Zhao Chen, Li Bixin, Yan Xiaojing, Li Yan

Abstract excerpt

DNA methyltransferase 3A (DNMT3A) catalyzes de novo DNA methylation and plays important roles in the pathogenesis of acute myeloid leukemia. However, the expression status of DNMT3A variants in acute myeloid leukemia remains obscure. This study aimed to assess the expression levels of alternative splicing of DNMT3A variants and explore their roles in acute myeloid leukemia (AML). DNMT3A variants gene expression...

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PMID: 29024628
DOI: 10.1016/j.bbrc.2017.10.041

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