Article
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jul 2011
Thol Felicitas, Damm Frederik, Lüdeking Andrea, Winschel Claudia, Wagner Katharina, Morgan Michael, Yun Haiyang, Göhring Gudrun, Schlegelberger Brigitte, Hoelzer Dieter, Lübbert Michael, Kanz Lothar, Fiedler Walter, Kirchner Hartmut, Heil Gerhard, Krauter Jürgen, Ganser Arnold, Heuser Michael
Abstract excerpt
PURPOSE: To study the incidence and prognostic impact of mutations in DNA methyltransferase 3A (DNMT3A) in patients with acute myeloid leukemia. PATIENTS AND METHODS: A total of 489 patients with AML were examined for mutations in DNMT3A by direct sequencing. The prognostic impact of DNMT3A mutations was evaluated in the context of other clinical prognostic markers and genetic risk factors (cytogenetic risk...
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