Article
KIR3DS1/L1 and HLA-Bw4-80I are associated with HIV disease progression among HIV typical progressors and long-term nonprogressors.
BMC infectious diseases - 2 Sept 2013
Jiang Yongjun, Chen Ou, Cui Chen, Zhao Bin, Han Xiaoxu, Zhang Zining, Liu Jing, Xu Junjie, Hu Qinghai, Liao Christina, Shang Hong
Abstract excerpt
BACKGROUND: Natural killer (NK) cells have emerged as pivotal players in innate immunity, especially in the defense against viral infections and tumors. Killer immunoglobulin-like receptors (KIRs)--an important recognition receptor expressed on the surface of NK cells--regulate the inhibition and/or activation of NK cells after interacting with human leukocyte antigen (HLA) class I ligands. Various KIR genes...
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