A genetic fingerprint associated with durable HIV remission after interruption of antiretroviral treatment: ANRS VISCONTI/PRIMO.

doi:10.1016/j.medj.2025.100670

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A genetic fingerprint associated with durable HIV remission after interruption of antiretroviral treatment: ANRS VISCONTI/PRIMO.

Med (New York, N.Y.) - 8 Aug 2025

Essat Asma, Chapel Anaïs, Amokrane Kahina, Monceaux Valérie, Didier Céline, Melard Adeline, Gardiennet Elise, Avettand-Fenoel Véronique, Orr Sylvie, Boufassa Faroudy, Lambotte Olivier, Müller-Trutwin Michaela, Lécuroux Camille, Chéret Antoine, Goujard Cécile, Rouzioux Christine, Caillat-Zucman Sophie, Hocqueloux Laurent, Scott-Algara Daniel, Meyer Laurence, Sáez-Cirión Asier

Abstract excerpt

BACKGROUND: There is currently no curative treatment for HIV-1 infection. However, some individuals (defined as posttreatment controllers) durably control viremia after the discontinuation of antiretroviral therapy (ART). Although the ability to achieve this HIV-1 remission status is enhanced by early treatment initiation, the mechanisms leading to posttreatment HIV-1 control remain unclear. METHODS: We...

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PMID: 40300610
DOI: 10.1016/j.medj.2025.100670
PMCID: PMC12335927

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