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Article

Earlier onset of Alzheimer's disease in men with Down syndrome.

Neurology - 1 Apr 1998

Schupf N, Kapell D, Nightingale B, Rodriguez A, Tycko B, Mayeux R

Abstract excerpt

BACKGROUND: Virtually all individuals with Down syndrome (DS) have neuropathologic changes characteristic of Alzheimer's disease (AD) beginning at 40 years of age. Few studies have examined factors that influence age at onset of AD in DS. We investigated whether sex differences in age at onset an...

Topics

Adult
Age of Onset
Aged
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Down Syndrome
Female
Genotype
Humans
Male
Middle Aged
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sex Distribution

Source

Identifiers

PMID: 9566384
DOI: 10.1212/wnl.50.4.991

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9566384-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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