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Article

Earlier onset of Alzheimer's disease in men with Down syndrome.

Neurology - 1 Apr 1998

Schupf N, Kapell D, Nightingale B, Rodriguez A, Tycko B, Mayeux R

Abstract excerpt

BACKGROUND: Virtually all individuals with Down syndrome (DS) have neuropathologic changes characteristic of Alzheimer's disease (AD) beginning at 40 years of age. Few studies have examined factors that influence age at onset of AD in DS. We investigated whether sex differences in age at onset and risk of AD among adults with DS are similar to those observed in the general population and whether the effect of sex...

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Source

Identifiers

PMID: 9566384
DOI: 10.1212/wnl.50.4.991

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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