Article
Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome.
JAMA neurology - 1 Aug 2021
Bejanin Alexandre, Iulita Maria Florencia, Vilaplana Eduard, Carmona-Iragui Maria, Benejam Bessy, Videla Laura, Barroeta Isabel, Fernandez Susana, Altuna Miren, Pegueroles Jordi, Montal Victor, Valldeneu Silvia, Giménez Sandra, González-Ortiz Sofía, Muñoz Laia, Padilla Concepción, Aranha Mateus Rozalem, Estellés Teresa, Illán-Gala Ignacio, Belbin Olivia, Camacho Valle, Wilson Liam Reese, Annus Tiina, Osorio Ricardo S, Videla Sebastián, Lehmann Sylvain, Holland Anthony J, Zetterberg Henrik, Blennow Kaj, Alcolea Daniel, Clarimon Jordi, Zaman Shahid H, Blesa Rafael, Lleó Alberto, Fortea Juan
Abstract excerpt
Importance: Alzheimer disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Previous studies have suggested that the APOE ɛ4 allele plays a role in the risk and age at onset of dementia in DS; however, data on in vivo biomarkers remain scarce. Objective: To investigate the association of the APOE ɛ4 allele with clinical and multimodal biomarkers of AD in adults with DS. Design,...
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