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Article

Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

Neurobiology of aging - 1 Aug 2017

Lee Joseph H, Lee Annie J, Dang Lam-Ha, Pang Deborah, Kisselev Sergey, Krinsky-McHale Sharon J, Zigman Warren B, Luchsinger José A, Silverman Wayne, Tycko Benjamin, Clark Lorraine N, Schupf Nicole

Abstract excerpt

Individuals with Down syndrome (DS) overexpress many genes on chromosome 21 due to trisomy and have high risk of dementia due to the Alzheimer's disease (AD) neuropathology. However, there is a wide range of phenotypic differences (e.g., age at onset of AD, amyloid β levels) among adults with DS, suggesting the importance of factors that modify risk within this particularly vulnerable population, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28554490
DOI: 10.1016/j.neurobiolaging.2017.04.018
PMCID: PMC5603247

Genes

CST3
MARK4
APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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