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Article

Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development.

Molecular and cellular biology - 1 Jan 2012

Tinguely Aurélien, Chemin Guillaume, Péron Sophie, Sirac Christophe, Reynaud Stéphane, Cogné Michel, Delpy Laurent

Abstract excerpt

Immunoglobulin (Ig) genes naturally acquire frequent premature termination codons during the error-prone V(D)J recombination process. Although B cell differentiation is linked to the expression of productive Ig alleles, the transcriptional status of nonfunctionally recombined alleles remains unclear. Here, we tracked transcription and posttranscriptional regulation for both Ig heavy-chain (IgH) alleles in mice...

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Identifiers

PMID: 22037763
DOI: 10.1128/MCB.06138-11
PMCID: PMC3255717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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