Article
The Ig heavy chain protein but not its message controls early B cell development.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2020
Aslam Muhammad Assad, Alemdehy Mir Farshid, Hao Bingtao, Krijger Peter H L, Pritchard Colin E J, de Rink Iris, Muhaimin Fitriari Izzatunnisa, Nurzijah Ika, van Baalen Martijn, Kerkhoven Ron M, van den Berk Paul C M, Skok Jane A, Jacobs Heinz
Abstract excerpt
Development of progenitor B cells (ProB cells) into precursor B cells (PreB cells) is dictated by immunoglobulin heavy chain checkpoint (IgHCC), where the IgHC encoded by a productively rearranged Igh allele assembles into a PreB cell receptor complex (PreBCR) to generate signals to initiate this transition and suppressing antigen receptor gene recombination, ensuring that only one productive Igh allele is...
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