Multiple RNA surveillance mechanisms cooperate to reduce the amount of nonfunctional Ig kappa transcripts.

doi:10.4049/jimmunol.0902949

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Article

Multiple RNA surveillance mechanisms cooperate to reduce the amount of nonfunctional Ig kappa transcripts.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2010

Chemin Guillaume, Tinguely Aurélien, Sirac Christophe, Lechouane Fabien, Duchez Sophie, Cogné Michel, Delpy Laurent

Abstract excerpt

Random V(D)J junctions ensure that the diversity of the Ig primary repertoire is adapted to the vast heterogeneity of Ags. In two-thirds of cases, recombination between variable segments induces a frameshift in the open reading frame and generates a premature termination codon. In B cells harboring biallelic V(D)J rearrangement of Ig genes, transcription is known to occur on both the functional and nonfunctional...

Topics

Alleles
Animals
Cell Differentiation
Cell Line, Tumor
Codon, Nonsense
Codon, Terminator
Down-Regulation
Frameshift Mutation
Gene Rearrangement, B-Lymphocyte, Light Chain
Immunoglobulin kappa-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Plasma Cells

RNA Splicing

RNA, Messenger

Recombination, Genetic

Stem Cells

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 20357261
DOI: 10.4049/jimmunol.0902949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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