Article
Transcription of productive and nonproductive VDJ-recombined alleles after IgH allelic exclusion.
The EMBO journal - 3 Oct 2007
Daly Janssen, Licence Steve, Nanou Aikaterini, Morgan Geoff, Mårtensson Inga-Lill
Abstract excerpt
The process of allelic exclusion ensures that each B cell expresses a B-cell receptor encoded by only one of its Ig heavy (IgH) and light (IgL) chain alleles. Although its precise mechanism is unknown, recruitment of the nonfunctional IgH allele to centromeric heterochromatin correlates with the establishment of allelic exclusion. Similarly, recruitment in activated splenic B cells correlates with cell division....
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