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Article

Physiological and druggable skipping of immunoglobulin variable exons in plasma cells.

Cellular & molecular immunology - 1 Oct 2019

Ashi Mohamad Omar, Srour Nivine, Lambert Jean-Marie, Marchalot Anne, Martin Ophélie, Le Noir Sandrine, Pinaud Eric, Ayala Maria Victoria, Sirac Christophe, Saulière Jérôme, Moreaux Jérôme, Cogné Michel, Delpy Laurent

Abstract excerpt

The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered splicing (NAS) events. Remarkably, the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell (PC) lifespan....

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Identifiers

PMID: 30127381
DOI: 10.1038/s41423-018-0160-6
PMCID: PMC6804933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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