Article
Physiological and druggable skipping of immunoglobulin variable exons in plasma cells.
Cellular & molecular immunology - 1 Oct 2019
Ashi Mohamad Omar, Srour Nivine, Lambert Jean-Marie, Marchalot Anne, Martin Ophélie, Le Noir Sandrine, Pinaud Eric, Ayala Maria Victoria, Sirac Christophe, Saulière Jérôme, Moreaux Jérôme, Cogné Michel, Delpy Laurent
Abstract excerpt
The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered splicing (NAS) events. Remarkably, the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell (PC) lifespan....
Topics
- Alleles
- Animals
- B-Lymphocytes
- Cell Differentiation
- Endoplasmic Reticulum Stress
- Exons
- Genetic Variation
- Immunoglobulin Heavy Chains
- Introns
- Mice
- Mice, Inbred C57BL
- Nonsense Mediated mRNA Decay
- Plasma Cells