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Article

Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2011

Lutz Johannes, Heideman Marinus R, Roth Edith, van den Berk Paul, Müller Werner, Raman Chander, Wabl Matthias, Jacobs Heinz, Jäck Hans-Martin

Abstract excerpt

B-lymphocyte development is dictated by the protein products of functionally rearranged Ig heavy (H) and light (L) chain genes. Ig rearrangement begins in pro-B cells at the IgH locus. If pro-B cells generate a productive allele, they assemble a pre-B cell receptor complex, which signals their differentiation into pre-B cells and their clonal expansion. Pre-B cell receptor signals are also thought to contribute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21670279
DOI: 10.1073/pnas.1019224108
PMCID: PMC3127927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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