Article
Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells.
Nucleic acids research - 1 Aug 2013
Holwerda Sjoerd J B, van de Werken Harmen J G, Ribeiro de Almeida Claudia, Bergen Ingrid M, de Bruijn Marjolein J W, Verstegen Marjon J A M, Simonis Marieke, Splinter Erik, Wijchers Patrick J, Hendriks Rudi W, de Laat Wouter
Abstract excerpt
In developing B cells, the immunoglobulin heavy chain (IgH) locus is thought to move from repressive to permissive chromatin compartments to facilitate its scheduled rearrangement. In mature B cells, maintenance of allelic exclusion has been proposed to involve recruitment of the non-productive IgH allele to pericentromeric heterochromatin. Here, we used an allele-specific chromosome conformation capture combined...
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