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Article

A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production.

The Journal of experimental medicine - 11 Jan 2016

Srour Nivine, Chemin Guillaume, Tinguely Aurélien, Ashi Mohamad Omar, Oruc Zéliha, Péron Sophie, Sirac Christophe, Cogné Michel, Delpy Laurent

Abstract excerpt

Aberrantly rearranged immunoglobulin (Ig) alleles are frequent. They are usually considered sterile and innocuous as a result of nonsense-mediated mRNA decay. However, alternative splicing can yield internally deleted proteins from such nonproductively V(D)J-rearranged loci. We show that nonsense codons from variable (V) Igκ exons promote exon-skipping and synthesis of V domain-less κ light chains (ΔV-κLCs)....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26666261
DOI: 10.1084/jem.20131511
PMCID: PMC4710196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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