Article
Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk.
BMC medical genetics - 26 Oct 2011
Simonson Matthew A, Wills Amanda G, Keller Matthew C, McQueen Matthew B
Abstract excerpt
BACKGROUND: Traditional genome-wide association studies are generally limited in their ability explain a large portion of genetic risk for most common diseases. We sought to use both traditional GWAS methods, as well as more recently developed polygenic genome-wide analysis techniques to identify subsets of single-nucleotide polymorphisms (SNPs) that may be involved in risk of cardiovascular disease, as well as...
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