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Article

A positively selected APOBEC3H haplotype is associated with natural resistance to HIV-1 infection.

Evolution; international journal of organic evolution - 1 Nov 2011

Cagliani Rachele, Riva Stefania, Fumagalli Matteo, Biasin Mara, Caputo Sergio Lo, Mazzotta Francesco, Piacentini Luca, Pozzoli Uberto, Bresolin Nereo, Clerici Mario, Sironi Manuela

Abstract excerpt

APOBEC3 genes encode cytidine deaminases endowed with the ability to inhibit retroviruses and retrotransposons. These genes have been targets of natural selection throughout primate evolutionary history. We analyzed their selection pattern in human populations observing that APOBEC3F and 3G are neutrally evolving. Conversely, nucleotide diversity was extremely high for APOBEC3H, and most tests rejected the...

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Identifiers

PMID: 22023594
DOI: 10.1111/j.1558-5646.2011.01368.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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