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Article

Genome-scale detection of positive selection in nine primates predicts human-virus evolutionary conflicts.

Nucleic acids research - 13 Oct 2017

van der Lee Robin, Wiel Laurens, van Dam Teunis J P, Huynen Martijn A

Abstract excerpt

Hotspots of rapid genome evolution hold clues about human adaptation. We present a comparative analysis of nine whole-genome sequenced primates to identify high-confidence targets of positive selection. We find strong statistical evidence for positive selection in 331 protein-coding genes (3%), pinpointing 934 adaptively evolving codons (0.014%). Our new procedure is stringent and reveals substantial artefacts...

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Source

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Identifiers

PMID: 28977405
DOI: 10.1093/nar/gkx704
PMCID: PMC5737536

Genes

CENPO
CENPT
MAVS
SAMHD1
TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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