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Joint effects of balancing selection and population bottlenecks on the evolution of a regulatory region of human anti-viral <i>APOBEC3</i>

2023-07-19

Abstract excerpt

Human anti-viral APOBEC3s are crucial components of the innate immune response, playing a key role in inhibiting viral replication and proliferation by inducing mutations in viral genomes. In this study, in a regulatory region of ∼16 kb in the APOBEC3 gene cluster on human chromosome 22, we identified three distinct haplogroups that are maintained at high frequencies in both African and non-African populations to...

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Identifiers and source

Literature Corpus work
a7dd782b-7d82-51d1-a7ef-53617b5df337
DOI
10.1101/2023.07.18.549600
Open publication

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Joint effects of balancing selection and population bottlenecks on the evolution of a regulatory region of human anti-viral <i>APOBEC3</i>DOI 10.1101/2023.07.18.549600
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