Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses.

PLoS pathogens - 1 Oct 2016

Wittkopp Cristina J, Adolph Madison B, Wu Lily I, Chelico Linda, Emerman Michael

Abstract excerpt

Humans express seven human APOBEC3 proteins, which can inhibit viruses and endogenous retroelements through cytidine deaminase activity. The seven paralogs differ in the potency of their antiviral effects, as well as in their antiviral targets. One APOBEC3, APOBEC3C, is exceptional as it has been found to only weakly block viruses and endogenous retroelements compared to other APOBEC3s. However, our positive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytidine Deaminase
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Research and Treatment

Share to Lentivirus Infections

Share to Polymerase Chain Reaction

Share to Polymorphism, Single Nucleotide

Share to Primates

Source

Open in PubMed Open full text

Identifiers

PMID: 27732658
DOI: 10.1371/journal.ppat.1005865
PMCID: PMC5061367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses.PMID 27732658Read ↗

Human APOBEC3 Variations and Viral InfectionSemantic proximity Read ↗

Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancerSemantic proximity Read ↗

APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome.Semantic proximity Read ↗

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.Semantic proximity Read ↗

APOBEC3 family proteins as drivers of virus evolutionSemantic proximity Read ↗

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous RetroelementsSemantic proximity Read ↗

APOBEC3G Splicing Defects in Nonhuman Primate Models Result in Disparate Viral Mutational Profiles Relative to HumansSemantic proximity Read ↗

Leveraging APOBEC3 Proteins to Alter the HIV Mutation Rate and Combat AIDSSemantic proximity Read ↗

The role of cytidine deaminases on innate immune responses against human viral infections.Semantic proximity Read ↗

A positively selected APOBEC3H haplotype is associated with natural resistance to HIV-1 infection.Semantic proximity Read ↗

Natural APOBEC3C variants can elicit differential HIV-1 restriction activitySemantic proximity Read ↗

Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.