Article

PNLDC1 catalysis and postnatal germline function are required for piRNA trimming, LINE1 silencing, and spermatogenesis in mice

2023-12-27

Abstract excerpt

<h4>ABSTRACT</h4> PIWI-interacting RNAs (piRNAs) play critical and conserved roles in transposon silencing and gene regulation in the animal germline. Two distinct piRNA populations are present during mouse spermatogenesis: pre-pachytene piRNAs in fetal/neonatal testes and pachytene piRNAs in adult testes. PNLDC1 is required for both pre-pachytene piRNA and pachytene piRNA 3’ end maturation in multiple species. H...

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Literature Corpus work: 914508f5-33b9-59af-8afd-d1256821d576
DOI: 10.1101/2023.12.26.573375

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