Article

Structural identification of a selectivity filter in CFTR

2023-10-12

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that regulates transepithelial salt and fluid homeostasis. CFTR dysfunction leads to reduced chloride secretion into the mucosal lining of epithelial tissues, thereby causing the inherited disease cystic fibrosis. Although several structures of CFTR are available, our understanding of the ion-conduction pathway is incomplete. In p...

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Literature Corpus work: f4ad27e4-8f57-5641-a300-782ffe8a4c22
DOI: 10.1101/2023.10.11.561906

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