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Article

Single d(ApG)/cis-diamminedichloroplatinum(II) adduct-induced mutagenesis in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Burnouf D, Gauthier C, Chottard J C, Fuchs R P

Abstract excerpt

The mutation spectrum induced by the widely used antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) showed that cisDDP[d(ApG)] adducts, although they account for only 25% of the lesions formed, are approximately 5 times more mutagenic than the major GG adduct. We report the construction of vectors bearing a single cisDDP[d(ApG)] lesion and their use in mutagenesis experiments in Escherichia coli. The...

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Identifiers

PMID: 2201020
DOI: 10.1073/pnas.87.16.6087
PMCID: PMC54477

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