Article
Single d(ApG)/cis-diamminedichloroplatinum(II) adduct-induced mutagenesis in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Burnouf D, Gauthier C, Chottard J C, Fuchs R P
Abstract excerpt
The mutation spectrum induced by the widely used antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) showed that cisDDP[d(ApG)] adducts, although they account for only 25% of the lesions formed, are approximately 5 times more mutagenic than the major GG adduct. We report the construction of...
Topics
- Base Composition
- Base Sequence
- Cisplatin
- Codon
- Dinucleoside Phosphates
- Escherichia coli
- Genetic Vectors
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Phenotype
- Plasmids
- SOS Response, Genetics
- Transformation, Bacterial