Article
Induction of tandem-base change mutations.
Mutation research - 1 Aug 1994
Hutchinson F
Abstract excerpt
Four databases with sequence changes for 12000 mutations in mammalian and bacterial cells were searched for genotoxic agents inducing tandem mutations, in which two adjacent base pairs are changed. Ultraviolet light induces about one CC > TT per 10-20 mutations, and other tandem-base changes at about half that frequency. There is strong evidence that cis-diammine dichloroplatinum (II) induces tandems. These...
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