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Article

Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 1997

Fink S P, Reddy G R, Marnett L J

Abstract excerpt

The spectrum of mutations induced by the naturally occurring DNA adduct pyrimido[1,2-alpha]purin-10(3H)-one (M1G) was determined by site-specific approaches using M13 vectors replicated in Escherichia coli. M1G was placed at position 6256 in the (-)-strand of M13MB102 by ligating the oligodeoxynucleotide 5'-GGT(M1G)TCCG-3' into a gapped-duplex derivative of the vector. Unmodified and M1G-modified genomes...

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Identifiers

PMID: 9238032
DOI: 10.1073/pnas.94.16.8652
PMCID: PMC23062

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