Article
Enhanced mutagenesis during post-treatment incubation of Escherichia coli treated with cis-diamminedichloroplatinum(II).
Mutation research - 1 Jan 2000
Razaka H, Villani G, Hoffman J S, Defais M, Johnson N P
Abstract excerpt
Wild-type Escherichia coli were treated with cis-dichlorodiammineplatinum(II) (DDP) and then kept in a non-dividing state for 4 h. This post-treatment incubation did not increase survival, excision of platinum-DNA lesions was not observed, and post-treatment exposure to thiourea had no effect on the toxicity of DDP. In contrast, the mutation frequency increased by a factor of 3 and reached a plateau after 3 h...
Topics
- Cell Division
- Cisplatin
- DNA
- DNA Damage
- Escherichia coli
- Mutation
- Thiourea