Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs.

doi:10.1016/0022-2836(94)90010-8

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Article

Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs.

Journal of molecular biology - 4 Mar 1994

Yarema K J, Wilson J M, Lippard S J, Essigmann J M

Abstract excerpt

cis-Diamminedichloroplatinum(II) (cis-DDP) and cis,trans,cis-ammine(cyclohexylamine)-dibutyratodichloroplatinu m(IV) (ACDDP) are anticancer drugs that bind to DNA, forming replication blocking adducts. ACDDP, probably manifests its cytotoxicity through the metabolite cis-ammine(cyclohexylamine)di...

Topics

Antineoplastic Agents
Base Sequence
Carcinogens
Cisplatin
DNA
DNA Adducts
DNA Replication
DNA, Bacterial
Drug Design
Escherichia coli
Humans
Lac Operon
Molecular Sequence Data
Molecular Structure
Mutation
Organoplatinum Compounds
Point Mutation

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Open in PubMed

Identifiers

PMID: 8120885
DOI: 10.1016/0022-2836(94)90010-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8120885-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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