Article
Effects of cis-diamminedichloroplatinum(II) on Escherichia coli and bacteriophage systems.
Journal of biochemistry - 1 May 1998
Tanaka N, Saito H, Kimoto H, Taketo A
Abstract excerpt
The effects of cis-diamminedichloroplatinum(II) (cisplatin) on Escherichia coli cells and bacteriophages were investigated. The bacteriocidal effect of cisplatin was stronger on uvrA or recA mutants than on wild type cells. The drug, like UV, induced prophage development in lysogenic bacteria. Host cell reactivation of alpha3 replicative form (RF) I DNA treated with cisplatin in vitro was more efficient in wild...
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