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Article

Assessment of three epigenotypes in colorectal cancer by combined bisulfite restriction analysis.

Molecular carcinogenesis - 1 Dec 2012

Karpinski Pawel, Szmida Elzbieta, Misiak Blazej, Ramsey David, Leszczynski Przemyslaw, Bebenek Marek, Sedziak Tomasz, Grzebieniak Zygmunt, Jonkisz Anna, Lebioda Arleta, Sasiadek Maria M

Abstract excerpt

Recent investigations have demonstrated the clear heterogeneity of sporadic colorectal cancer (CRC) with regard to CpG island methylation. Two unsupervised cluster analyses revealed that CRCs form three distinct DNA methylation subsets, which are referred to as the high-, intermediate-, and low-methylation epigenotypes (HME, IME, and LME, respectively). A recent study by Yagi et al. found a fairly sensitive and...

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Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Genes, ras

Share to MutL Protein Homolog 1

Share to Proto-Oncogene Proteins B-raf

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 22006538
DOI: 10.1002/mc.20871

Genes

BRAF
KRAS
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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