Article
Intermediate- and low-methylation epigenotypes do not correspond to CpG island methylator phenotype (low and -zero) in colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2013
Karpinski Pawel, Walter Michael, Szmida Elzbieta, Ramsey David, Misiak Blazej, Kozlowska Joanna, Bebenek Marek, Grzebieniak Zygmunt, Blin Nikolaus, Laczmanski Lukasz, Sasiadek Maria M
Abstract excerpt
BACKGROUND: Most recent genome-wide studies on the CpG island methylation in colorectal cancer (CRC) have led to the discovery of at least 3 distinct methylation clusters. However, there remains an uncertainty whether the CRC clusters identified in these studies represent compatible phenotypes. METHODS: We carried out comprehensive genome-scale DNA methylation profiling by Illumina Infinium HumanMethylation27 of...
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