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Article

Three DNA methylation epigenotypes in human colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2010

Yagi Koichi, Akagi Kiwamu, Hayashi Hiroshi, Nagae Genta, Tsuji Shingo, Isagawa Takayuki, Midorikawa Yutaka, Nishimura Yoji, Sakamoto Hirohiko, Seto Yasuyuki, Aburatani Hiroyuki, Kaneda Atsushi

Abstract excerpt

PURPOSE: Whereas the CpG island methylator phenotype (CIMP) in colorectal cancer associates with microsatellite instability (MSI)-high and BRAF-mutation(+), the existence of an intermediate-methylation subgroup associated with KRAS-mutation(+) is controversial, and suitable markers for the subgroup have yet to be developed. Our aim is to clarify DNA methylation epigenotypes of colorectal cancer more...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20028768
DOI: 10.1158/1078-0432.CCR-09-2006

Genes

KRAS
BRAF
ELMO1
FBN2
HAND1
LOX
THBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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