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Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer

4 Oct 2022

Abstract excerpt

Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate-controlled study of over two thousand individual blood samples, we created, tested and explored the properties of a 5-hydroxymethylcytosine-based classifier to detect colorectal cancer (CRC). In an independent validation sample set, the classifier...

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PMID: 36195648
DOI: 10.1038/s41598-022-20975-1

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