Article
Two groups of DNA methylation markers to classify colorectal cancer into three epigenotypes.
Cancer science - 1 Jan 2011
Kaneda Atsushi, Yagi Koichi
Abstract excerpt
A subgroup of colorectal cancer (CRC) shows non-random accumulation of aberrant DNA methylation, so-called CpG island methylator phenotype (CIMP), which was associated with microsatellite instability and BRAF mutation. As just one group of methylation markers was suitable to extract CIMP+/CIMP-high, and had been commonly used in the "one-panel method", it had been unclear whether another cluster of CRC with DNA...
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