Article
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2007
Shen Lanlan, Toyota Minoru, Kondo Yutaka, Lin E, Zhang Li, Guo Yi, Hernandez Natalie Supunpong, Chen Xinli, Ahmed Saira, Konishi Kazuo, Hamilton Stanley R, Issa Jean-Pierre J
Abstract excerpt
Colon cancer has been viewed as the result of progressive accumulation of genetic and epigenetic abnormalities. However, this view does not fully reflect the molecular heterogeneity of the disease. We have analyzed both genetic (mutations of BRAF, KRAS, and p53 and microsatellite instability) and epigenetic alterations (DNA methylation of 27 CpG island promoter regions) in 97 primary colorectal cancer patients....
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Colonic Neoplasms
- CpG Islands
- DNA Methylation
- Epigenesis, Genetic
- Female
- Gene Expression Profiling