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Article

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.

Journal of cell science - 15 Oct 2011

Chartier François J-M, Hardy Émilie J-L, Laprise Patrick

Abstract excerpt

Drosophila Crumbs (Crb) and its mammalian ortholog CRB3 control epithelial polarity through poorly understood molecular mechanisms. Elucidating these mechanisms is crucial, because the physiology of epithelia largely depends on the polarized architecture of individual epithelial cells. In addition, loss of CRB3 favors tumor cell growth, metastasis and epithelial to mesenchymal transition (EMT). Using Drosophila...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21984807
DOI: 10.1242/jcs.092601

Genes

CRB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.PMID 21984807Read ↗

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.Semantic proximity Read ↗

Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.Semantic proximity Read ↗

Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death.Semantic proximity Read ↗

Crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster.Semantic proximity Read ↗

Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells.Semantic proximity Read ↗

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.Semantic proximity Read ↗

CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.Semantic proximity Read ↗

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.Semantic proximity Read ↗

DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila.Semantic proximity Read ↗

crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia.Semantic proximity Read ↗

CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.Semantic proximity Read ↗

The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.Semantic proximity Read ↗

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