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Article

crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia.

Cell - 1 Jun 1990

Tepass U, Theres C, Knust E

Abstract excerpt

We describe the molecular characterization of the Drosophila gene crumbs, which encodes an integral membrane protein with 30 EGF-like repeats in the extracellular part and exhibits a striking expression pattern. The protein is exclusively localized on the apical membranes of epithelial cells and concentrated at the borders between cells. Mutations in crumbs lead to severe disruptions in the organization of...

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Identifiers

PMID: 2344615
DOI: 10.1016/0092-8674(90)90189-l

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia.PMID 2344615Read ↗

crumbs and stardust, two genes of Drosophila required for the development of epithelial cell polarity.Semantic proximity Read ↗

CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.Semantic proximity Read ↗

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.Semantic proximity Read ↗

Crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster.Semantic proximity Read ↗

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.Semantic proximity Read ↗

Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells.Semantic proximity Read ↗

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.Semantic proximity Read ↗

CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.Semantic proximity Read ↗

Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.Semantic proximity Read ↗

Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size.Semantic proximity Read ↗

The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity.Semantic proximity Read ↗

Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium.Semantic proximity Read ↗

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