Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.

Nature - 14 Mar 2002

Izaddoost Shayan, Nam Sang-Chul, Bhat Manzoor A, Bellen Hugo J, Choi Kwang-Wook

Abstract excerpt

Drosophila Crumbs (Crb) is required for apical-basal polarity and is an apical determinant in embryonic epithelia. Here, we describe properties of Crb that control the position and integrity of the photoreceptor adherens junction and photosensitive organ, or rhabdomere. In contrast to normal photoreceptor adherens junctions and rhabdomeres, which span the depth of the retina, adherens junctions and rhabdomeres of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adherens Junctions
Share to Cell Polarity
Share to Cues

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Proteins

Share to Insect Proteins

Share to Morphogenesis

Share to Photoreceptor Cells, Invertebrate

Source

Identifiers

PMID: 11850624
DOI: 10.1038/nature720

Genes

CRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.PMID 11850624Read ↗

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.Semantic proximity Read ↗

Towards understanding CRUMBS function in retinal dystrophies.Semantic proximity Read ↗

CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function.Semantic proximity Read ↗

CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retinaSemantic proximity Read ↗

Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal laminationSemantic proximity Read ↗

The extracellular and intracellular regions of Crb2a play distinct roles in guiding the formation of the apical zonula adherens.Semantic proximity Read ↗

Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration.Semantic proximity Read ↗

CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.Semantic proximity Read ↗

Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.Semantic proximity Read ↗

Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.Semantic proximity Read ↗

Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosisSemantic proximity Read ↗

Crumbs homologue 1 in polarity and blindness.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.