Article
CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.
Mechanisms of development - 1 Dec 1993
Wodarz A, Grawe F, Knust E
Abstract excerpt
The gene crumbs (crb) of Drosophila encodes a transmembrane protein with 30 EGF-like and four laminin A G-domain-like repeats in its extracellular domain. Loss-of-function mutations lead to severe disorganization and degeneration of ectodermally derived embryonic epithelia. In embryos homozygous...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Drosophila
- Epidermal Growth Factor
- Epithelium
- Homozygote
- Laminin
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Phenotype
- Protein Structure, Tertiary