Article
CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.
Mechanisms of development - 1 Dec 1993
Wodarz A, Grawe F, Knust E
Abstract excerpt
The gene crumbs (crb) of Drosophila encodes a transmembrane protein with 30 EGF-like and four laminin A G-domain-like repeats in its extracellular domain. Loss-of-function mutations lead to severe disorganization and degeneration of ectodermally derived embryonic epithelia. In embryos homozygous for crb8F105, an amorphic allele, the CRUMBS protein is diffusely distributed in the cytoplasm instead of being...
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