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Article

DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila.

The Journal of cell biology - 16 Aug 2004

Sotillos Sol, Díaz-Meco María Teresa, Caminero Eva, Moscat Jorge, Campuzano Sonsoles

Abstract excerpt

Both in Drosophila and vertebrate epithelial cells, the establishment of apicobasal polarity requires the apically localized, membrane-associated Par-3-Par-6-aPKC protein complex. In Drosophila, this complex colocalizes with the Crumbs-Stardust (Sdt)-Pals1-associated TJ protein (Patj) complex. Genetic and molecular analyses suggest a functional relationship between them. We show, by overexpression of a...

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Identifiers

PMID: 15302858
DOI: 10.1083/jcb.200311031
PMCID: PMC2172211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila.PMID 15302858Read ↗

Kinase-activity-independent functions of atypical protein kinase C in Drosophila.Semantic proximity Read ↗

Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust.Semantic proximity Read ↗

The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells.Semantic proximity Read ↗

Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells.Semantic proximity Read ↗

The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.Semantic proximity Read ↗

An apical MRCK-driven morphogenetic pathway controls epithelial polarity.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

glaikit is essential for the formation of epithelial polarity and neuronal development.Semantic proximity Read ↗

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.Semantic proximity Read ↗

PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.Semantic proximity Read ↗

Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability.Semantic proximity Read ↗

Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.Semantic proximity Read ↗

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