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Article

The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.

The Journal of cell biology - 4 Mar 2013

Hayase Junya, Kamakura Sachiko, Iwakiri Yuko, Yamaguchi Yoshihiro, Izaki Tomoko, Ito Takashi, Sumimoto Hideki

Abstract excerpt

Formation of apico-basal polarity in epithelial cells is crucial for both morphogenesis (e.g., cyst formation) and function (e.g., tight junction development). Atypical protein kinase C (aPKC), complexed with Par6, is considered to translocate to the apical membrane and function in epithelial cell polarization. However, the mechanism for translocation of the Par6-aPKC complex has remained largely unknown. Here,...

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Identifiers

PMID: 23439680
DOI: 10.1083/jcb.201208150
PMCID: PMC3587828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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