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Article

Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death.

The Journal of cell biology - 17 Sept 2012

Chartier François J-M, Hardy Émilie J-L, Laprise Patrick

Abstract excerpt

Drosophila melanogaster Crumbs (Crb) and its mammalian orthologues (CRB1-3) share evolutionarily conserved but poorly defined roles in regulating epithelial polarity and, in photoreceptor cells, morphogenesis and stability. Elucidating the molecular mechanisms of Crb function is vital, as mutations in the human CRB1 gene cause retinal dystrophies. Here, we report that Crb restricts Rac1-NADPH oxidase-dependent...

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Share to Cell Polarity
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oxidoreductases

Share to Photoreceptor Cells, Invertebrate

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Share to Retinal Degeneration

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Source

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Identifiers

PMID: 22965909
DOI: 10.1083/jcb.201203083
PMCID: PMC3444775

Genes

CRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death.PMID 22965909Read ↗

Diverse functions and pathogenetic role of Crumbs in retinopathy.Semantic proximity Read ↗

Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal laminationSemantic proximity Read ↗

Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.Semantic proximity Read ↗

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.Semantic proximity Read ↗

Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration.Semantic proximity Read ↗

Towards understanding CRUMBS function in retinal dystrophies.Semantic proximity Read ↗

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.Semantic proximity Read ↗

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.Semantic proximity Read ↗

Crumbs homologue 1 in polarity and blindness.Semantic proximity Read ↗

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.Semantic proximity Read ↗

CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retinaSemantic proximity Read ↗

Retinal degeneration in a mouse model of CRB1 disease rescued by the photoreceptor-specific <i>CRB1-B</i> isoformSemantic proximity Read ↗

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