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Article

Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death.

The Journal of cell biology - 17 Sept 2012

Chartier François J-M, Hardy Émilie J-L, Laprise Patrick

Abstract excerpt

Drosophila melanogaster Crumbs (Crb) and its mammalian orthologues (CRB1-3) share evolutionarily conserved but poorly defined roles in regulating epithelial polarity and, in photoreceptor cells, morphogenesis and stability. Elucidating the molecular mechanisms of Crb function is vital, as mutatio...

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Share to Cell Polarity
Share to Epithelium
Share to NADPH Oxidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oxidoreductases

Share to Photoreceptor Cells, Invertebrate

Share to rac GTP-Binding Proteins

Share to Retinal Degeneration

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Source

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Identifiers

PMID: 22965909
DOI: 10.1083/jcb.201203083
PMCID: PMC3444775

Genes

CRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22965909-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death.PMID 22965909Read ↗

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Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.Semantic proximity Read ↗

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