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Article

Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells.

Journal of cell science - 1 Jul 2005

Fogg Vanessa C, Liu Chia-Jen, Margolis Ben

Abstract excerpt

The formation and maintenance of tight junctions is essential for the development of epithelial cell polarity. Recently, a number of conserved polarity-regulating proteins have been shown to localize to epithelial tight junctions, and to play a role in the regulation of tight junction formation. The Crumbs3/PALS1/PATJ protein complex localizes at epithelial tight junctions and interacts with the...

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Share to Amino Acid Sequence
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Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Gene Expression Regulation, Developmental

Share to Mammary Glands, Human

Share to Membrane Glycoproteins

Share to Tight Junctions

Source

Identifiers

PMID: 15976445
DOI: 10.1242/jcs.02412

Genes

PALS1
PATJ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells.PMID 15976445Read ↗

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.Semantic proximity Read ↗

DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila.Semantic proximity Read ↗

crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia.Semantic proximity Read ↗

The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.Semantic proximity Read ↗

The claudin Megatrachea protein complex.Semantic proximity Read ↗

Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.Semantic proximity Read ↗

Claudins and epithelial paracellular transport.Semantic proximity Read ↗

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.Semantic proximity Read ↗

Claudins in morphogenesis: Forming an epithelial tubeSemantic proximity Read ↗

Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout miceSemantic proximity Read ↗

Loss of polarity protein Par3 in the intestinal epithelium promotes colitis‐associated colorectal cancer progression by damaging tight junction assemblySemantic proximity Read ↗

Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization.Semantic proximity Read ↗

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