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Article

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.

Current biology : CB - 13 Apr 2010

Robinson Brian S, Huang Juang, Hong Yang, Moberg Kenneth H

Abstract excerpt

BACKGROUND: Altered expression of apicobasal polarity factors is associated with cancer in vertebrates and tissue overgrowth in invertebrates, yet the mechanisms by which these factors affect growth-regulatory pathways are not well defined. We have tested the basis of an overgrowth phenotype driven by the Drosophila protein Crumbs (Crb), which nucleates an apical membrane complex that functionally interacts with...

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Identifiers

PMID: 20362445
DOI: 10.1016/j.cub.2010.03.019
PMCID: PMC2855393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.PMID 20362445Read ↗

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.Semantic proximity Read ↗

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.Semantic proximity Read ↗

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.Semantic proximity Read ↗

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.Semantic proximity Read ↗

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth.Semantic proximity Read ↗

Kibra is a regulator of the Salvador/Warts/Hippo signaling network.Semantic proximity Read ↗

Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size.Semantic proximity Read ↗

The protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation.Semantic proximity Read ↗

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.Semantic proximity Read ↗

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling.Semantic proximity Read ↗

Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.Semantic proximity Read ↗

CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.Semantic proximity Read ↗

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