Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.

Nature - 14 Mar 2002

Pellikka Milena, Tanentzapf Guy, Pinto Madalena, Smith Christian, McGlade C Jane, Ready Donald F, Tepass Ulrich

Abstract excerpt

The apical transmembrane protein Crumbs is a central regulator of epithelial apical-basal polarity in Drosophila. Loss-of-function mutations in the human homologue of Crumbs, CRB1 (RP12), cause recessive retinal dystrophies, including retinitis pigmentosa. Here we show that Crumbs and CRB1 localize to corresponding subdomains of the photoreceptor apical plasma membrane: the stalk of the Drosophila photoreceptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adherens Junctions
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeleton

Share to Morphogenesis

Share to Photoreceptor Cells, Invertebrate

Share to Retina

Share to Sequence Homology

Share to Spectrin

Source

Identifiers

PMID: 11850625
DOI: 10.1038/nature721

Genes

CRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.PMID 11850625Read ↗

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.Semantic proximity Read ↗

CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.Semantic proximity Read ↗

Composition and function of the Crumbs protein complex in the mammalian retina.Semantic proximity Read ↗

Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration.Semantic proximity Read ↗

Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.Semantic proximity Read ↗

Towards understanding CRUMBS function in retinal dystrophies.Semantic proximity Read ↗

Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal laminationSemantic proximity Read ↗

Crumbs homologue 1 in polarity and blindness.Semantic proximity Read ↗

Diverse functions and pathogenetic role of Crumbs in retinopathy.Semantic proximity Read ↗

Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size.Semantic proximity Read ↗

CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.Semantic proximity Read ↗

Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.